By binding to the GLP-1 receptor, both drugs work to reduce food intake and increase insulin sensitivity. However, Tirzepatide is a dual agonist that targets both the GLP-1 and glucagon receptors, while Semaglutide is a single GLP-1 receptor agonist. As such, some have felt that Tirzepatide may be more effective in weight loss. You can speak to your doctor too to help evaluate the best option for you.