On average, users of GLP-1 medications experience a weight reduction of approximately 15%, compared to just 2.4% with a placebo. Notably, even a modest weight loss of 5% can significantly benefit health conditions such as hypertension, cholesterol issues, cardiovascular diseases, PCOS, osteoarthritis, and more. However, GLP-1 medications work best with diet, exercise and lifestyle changes for sustained weight loss after you stop taking the medication.